Always a Scientist.

Publications

2025

Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behaviors

Corbit, V.L., Piantadosi, S.C., Wood, J.T., Madireddy, S.S., Choi, C.J.Y., Witten, I.B., Gittis, A.H., and Ahmari, S.E. 
2025, Cell Reports, 44(1), PMID: 39786992

schematic showing mouse brains slides with anterolateral motor cortex projecting to central striatum. Underneath, an illustrated grooming mouse with the words "Mouse Self-Initiated Grooming." On the right, two schematized graphs showing that central striatum increases activity at the start of grooming, wile ALM increases activity towards the end of grooming.
On the left, schematized neurons showing 2 striatal spiny projection neurons with arrows pointing out and the text "Striatal activity affects behavior", and a single FSI that says "Fast-spiking interneurons quiet down striatal activity". On the right, an illustrated half-coronal slice from mouse brain, with callout boxes for Dorsolateral Striatum, Central Striatum, and Ventral Striatum.
2019

A model of restraint: Nucleus accumbens fast-spiking interneurons inhibit unwanted actions.

Corbit, V.L., Gittis, A.H., and Ahmari, S.E. 
2019, Biological Psychiatry, 86(11): 804:806 
PMID: 31668219

2019

Strengthened inputs from supplementary motor cortex to striatum in a mouse model of compulsive behavior.

Corbit, V.L., Manning, E.E., Gittis, A.H., and Ahmari, S.E. 
2019, Journal of Neuroscience, 39(15): 2965-2975, PMID: 30737313

At the top, illustrated mouse brain slices showing medial prefrontal cortex projections to dorsomedial striatum or motor cortex projections to dorsolateral striatum. On the bottom, a graph shows how, during motor task learning, activity is more disparate between the circuits, but becomes more similar as a mouse learns the task.
2017

A corticostriatal balancing act supports skill learning

 Corbit, V.L., Ahmari, S.E., & Gittis, A.H.
2017, Neuron, 96(2): 253-255, PMID: 29024650 

2016

Pallidostriatal projections promote β oscillations in a dopamine-depleted biophysical network model

Corbit, V.L.*, Whalen, T.C.*, Zitelli, K.T., Crilly, S.Y., Rubin, J.E., Gittis, A.H.
2016, Journal of Neuroscience, 36(20): 5556-5571, PMID: 27194335

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